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Check out the hottest fashion, photos, movies and TV shows Breitbart TV is the home of the hottest video on politics, world events, culture, and media. The latest news and headlines from Yahoo News. Get breaking news stories and indepth coverage with videos and photos. Music News Billboard. NOVA Official Website Cancer Warrior. Cancer Warrior. PBS Airdate February 2. NARRATOR Deep in this freezer is a drug of incalculable value. Years in development and millions of dollars spent on research, it is now being tested in human patients. Its an experimental cancer drug called Endostatin, and if it works, it could profoundly change the way we treat cancer. John Matt is one of the chosen few selected to test Endostatin at the University of Wisconsin Comprehensive Cancer Center. He is part of what some have called the most anticipated clinical trial in medical history. John gets 1. 2 vials of Endostatin every day. Unlike other cancer drugs, its not a poison. So far, its had fewer side effects than aspirin. Endostatin attacks cancer in a way that is so new, so radical, that most experts laughed at the idea when it was first proposed by Dr. Judah Folkman. Forty years ago he stumbled upon a cluea hidden secret about how cancer really works. It would become his lifelong quest, to understand this relentless killer and find a better treatment for cancer patients. JUDAH FOLKMAN Childrens HospitalHarvard Medical School Patients going through these trials are in a desperate situation. Nothing else has worked and theres little time left and they have a fast clock running. We all have a clock but theirs is very fast. And so theyre very scared. JOHN MATT Endostatin trial participant I know. I think my tumor is still growing slightly right now. NARRATOR John Matt has very advanced cancer. He has failed every other therapy hes tried. Endostatin may be his last, best hope. But will it work NARRATOR Seven days a week John Matt drives three hours back and forth to the hospital to get his Endostatin infusion. Cancer Warrior Written, Produced and Directed by Nancy Linde Narrated by Liev Schreiber Edited by Doug Quade Associate Producers Andrea Cross Marty Johnson Danuta Forbes. Fighting cancer has become his full time job and its the toughest battle of his life. JOHN MATT I know I could die. I should have died a few years ago. So I already know that Im living on, as they say, borrowed time. I want it to work. And were putting everything we can into making it work. NARRATOR John is the sixteenth patient in Wisconsin to receive Endostatin. There are many more hoping to be number 1. DUANE GAY Reporter and Endostatin Trial Participant Kathy and Jerry, this is more than just a story. NARRATOR Duane Gay is a well known reporter in Milwaukee, Wisconsin. DUANE GAY Its really the inside story of two family farmers. NARRATOR In August of 1. Duane had just received the worst news of his life. DUANE GAY I was told, Not only is there extensive cancer in your lungs, numerous tumors, but weve found a large tumor in your liver. Here we were just married one year and planning a long life together and now were being told that I probably wont be around in six months. NARRATOR Duane and his wife Teri stopped building the house they had dreamed about for a decade and started on a long, difficult medical odyssey. He had extensive surgery followed by months of chemotherapy. DUANE GAY Chemotherapy is a hard thing to partner with because its a poison. And you walk into the hospital to get your chemotherapy feeling a little bit okay, and you leave feeling worse. NARRATOR Duane and Teri prayed every morning but the news just got worse. Screen-Shot-2017-01-30-at-7.08.59-AM-e1485781776424.png' alt='Watch The Tenth Man Online Forbes' title='Watch The Tenth Man Online Forbes' />His cancer was still growing and there was nothing more his doctors could do. Eighty miles away, in Madison, Wisconsin, Jim Thomas was inundated with patients trying to get into the Endostatin clinical trial. JAMES P. THOMAS University Of Wisconsin Cancer Center Over 4. The total number of patients is probably going to be in the low twenties, as far as how many patients will actually receive Endostatin here. This is Mr. Gay. Hes a 4. NARRATOR This is how the most important decision in Duane Gays life will be made. His chances of getting into this study are slim. He has to have the right kind of tumors in places where they can be monitored and easily biopsied. FRED LEE Probably the best one would be to biopsy this lesion here. Theres some very accessible tumor. JAMES P. THOMAS This gentleman is certainly an excellent candidate, so I think well approach him and ask him about entering into the study. FRED LEESounds great. DUANE GAY You have a good connection. NARRATOR In June of 2. Duane Gay received his first infusion of Endostatin. From now on, he has to come to the hospital seven days a week. Its a full time commitment. DUANE GAY For the next couple of months this is my job. And its a six and a half, seven hour day on the easy days. But I think its a small price to pay when you think about it. Ive worked a lot harder at things for less. NARRATOR This is a Phase One clinical trial and the dose starts out very low. The doctors are mainly looking for side effects, but the patients want Endostatin to stop or shrink their cancer. JAMES P. THOMAS Patients that are going into phase one trials, they really are heroic in many aspects. We really cant advise them about whether something might make them very sick. We have no idea whether its going to be effective or not. DUANE GAYThats good, thanks. I dont want to sound over dramatic about it, but Ill tell you the way I look at it. Its a war, and this is an enemy that has stolen too many lives and rained misery onto too many families. But I feel honored and humbled to be a soldier and hit that beach. And thats honestly the way that I feel about it right now. NARRATOR This is Childrens Hospital in Boston, an important battlefield in the war against cancer, and where Endostatin was discovered in the laboratory of Dr. Judah Folkman. It was a hard won discovery4. C. EVERETT KOOP Childrens Hospital of Philadelphia 1. United States Surgeon General 1. When the history of medicine is written, it will be a story of a tremendous impact that was, at the beginning, pooh poohed by his colleagues, at the end, proven to be what he said it would be and to have real, honest to goodness, practical value in the lives of patients, which is what Judah started out to do. NARRATOR Today, treating cancer often involves extreme measures and some of the most poisonous substances known. DON INGBER Childrens HospitalHarvard Medical School Conventional cancer drugs, most of which are still derivatives of, basically, the mustard gases used in warfare in World War I and are really toxic to any cell, have the known side effects of you losing your hair, losing your immune response, affecting your intestinal tract. NARRATOR Another problem with chemotherapy is drug resistance, which occurs when cancer cells mutate and become resistant to drugs that once worked on them. But Endostatin doesnt attack the cancer cells at all. It goes after normal cells, the ones that feed the tumor and allow it to grow. Starving cancer by cutting off its food supply was Dr. Folkmans revolutionary idea, which arose almost by accident more than 4. In 1. 96. 1 the U. S. Navy introduced the nuclear powered aircraft carrier. It was designed to stay at sea for months at a time. But there was a problem. The blood supply could only be stored for about three weeks. To help find a long lasting substitute for whole blood the Navy drafted young doctors, among them a surgeon named Judah Folkman. JUDAH FOLKMAN I was assigned to work on the problem of, could you dry the hemoglobin part of blood, the red part, like you dry coffee, and then reconstitute it by adding salt water and have it all ready to goNARRATOR Dr. Folkmans job was to find out if reconstituted hemoglobin could keep tissue alive like real blood does. With his colleague Fred Becker, Judah Folkman built a crude imitation of a circulatory system and attached a living organ, a rabbit thyroid. When the pump was turned on, the hemoglobin began to circulate and sure enough, the thyroid gland thrived. Then Dr. Folkman tried something that would turn this blood experiment into a four decade quest to understand cancer. To see if the hemoglobin solution could not only sustain an organ but support new growth, Dr.